Masaccio
The Pisa Polyptych: Madonna and Child with Angels

1426
Wood, 135.5 x 75 cm.
National Gallery, London
The painting is the central panel of a large, 19 pieces winged altar executed for a chapel of the Carmelite Church in Pisa. Ten other panels of the altarpiece are in various museums.

More of the Virgin Enthroned

Source: Web Gallery of Art