PUBLICATIONS & PRESENTATIONS

Click on a link below to jump to that section of the list. To view a copy of the list in PDF form, click HERE.

Publications
Patents
Conference Abstracts


Publications

1. Synthesis of Substituted Pyrrolo[2,3-e][1,3,4]thiadiazine 4,4-Dioxides, Chad E. Stephens and J. Walter Sowell, Sr. J. Heterocyclic Chem. 1996, 33, 1615. Presented at National ACS Meeting, New Orleans, April, 1996.

2. Chain-Length Variation in N-Alkyl-2-Pyrrolidinones: The Effect on Enhancement Activity In Vitro, B. B. Michniak, D. A. Godwin, C. E. Stephens, and J. W. Sowell, Sr. Pharm. Res. 1996, 13 (9), S-374.

3. Synthesis of Novel Heterocycles from 2-Amino-3-cyanomethylsulfonyl-4,5-dimethylfuran. Chad E. Stephens and J. Walter Sowell, Sr. J. Heterocyclic Chem. 1997, 34, 857. Presented at National ACS Meeting, San Francisco, April, 1997.

4. Synthesis of Novel Heterocycles from 2-Amino-3-(cyanomethylsulfonyl)thiophene, Chad E. Stephens and J. Walter Sowell, Sr. J. Heterocyclic Chem. 1998, 35, 927.

5. Synthesis and Cyclization Reactions of 2-Amino-3-[(methoxycarbonyl)methylsulfonyl]pyrroles and Thiophene, Chad E. Stephens and J. Walter Sowell, Sr. J. Heterocyclic Chem., 1998, 35, 933.

6. Synthesis of Methyl 3-Amino-4-aryl(or methyl)sulfonyl-2-thiophenecarboxylates from 3-Alkoxy-2-aryl(or methyl)sulfonylacrylonitriles, Chad E. Stephens, Matthew B. Price, and J. Walter Sowell, Sr. J. Heterocyclic Chem. 1999, 36, 659.

7. Palladium Catalyzed Cross-Coupling Reactions for the Synthesis of 2,5-Disubstitutedfurans, Arvind Kumar, Chad E. Stephens, and David W. Boykin. Heterocyclic Comm. 1999, 5, 301.

8. An Interesting Synthesis of Thieno[2,3-d][1,2,3]thiadiazole via Decomposition/Recyclization of 3-Methoxycarbonyl-1H-thieno[2,3-e][1,3,4]thiadiazine 4,4-Dioxide. Chad E. Stephens and J. Walter Sowell, Sr., J. Heterocyclic Chem. 2000, 37, 191.

9. Synthesis of Deuterium-Labelled 2,5-Bis(4-amidinophenyl)furan, 2,5-Bis[4-(methoxyamidino)-phenyl]furan and 2,7-Diamidinocarbazole. C. E. Stephens, D. A. Patrick, H. Chen, R. R. Tidwell, and D. W. Boykin, J. Labelled Cmpd. Radiopharm. 2001, 44, 197.

10. Synthesis and Antiviral/Antitumor Evaluation of 2-Amino- and 2-Carboxamido-3-(arylsulfonyl)thiophenes and Related Compounds as a New Class of Diarylsulfones. C. E. Stephens, T. M. Felder, J. W. Sowell, Sr., G. Andrei, J. Balzarini, R. Snoeck, and E. De Clercq, Bioorg. Med. Chem. 2001, 9, 1123 (2001). Presented at National ACS Meeting, New Orleans, September, 1999.

11. Diguanidino and “Reversed Diamidino” 2,5-Diarylfurans as Antimicrobial Agents. C. E. Stephens, F. Tanious, S. Kim, W. D. Wilson, W. A. Schell, J. R. Perfect, S. G. Franzblau and D. W. Boykin, J. Med. Chem. 2001, 44, 1741. Presented at ACS National Meeting, San Diego, April, 2001.

12. Evaluation of the Influence of Compound Structure on Stacked-Dimer Formation in the DNA Minor Groove. L. Wang, C. Carrasco, A. Kumar, C. E. Stephens, C. Bailly, D. W. Boykin and W. D. Wilson, Biochemistry 2001, 40, 2511.

13. Characterizing the Fragmentations of 2,5-Bis(4-amidinophenyl)furan-bis-O-methylamidoxime and Selected Metabolites Using Ion Trap Mass Spectrometry. L. Zhou, R. D. Voyksner, C. E. Stephens, M. Anbazhagen, D. W. Boykin, J. E. Hall, and R. R. Tidwell, Rapid Comm. Mass Spec. 2002, 16, 1078.

14. Distribution of Furamidine Analogues in Tumor Cells: Influence of the Number of Positive Charges. A. Lansiaux, L. Dassonneville, M. Facompre, A. Kumar, C. E. Stephens, M. Bajic, F. Tanious, W. D. Wilson, D. W. Boykin and C. Bailly, J. Med. Chem. 2002, 45, 1994.

15. Palladium-Catalyzed N-Arylation of O-Methylamidoximes. Mariappan Anbazhagan, C. E. Stephens and D. W. Boykin, Tetrahedron Lett. 2002, 43, 4221.

16. Regioselective Cleavage of O-Benzyl-N-arylamidoximes: Synthesis of N-aryl amidines and amidoximes. M. Anbazhagan, D. W. Boykin, and C. E. Stephens, Tetrahedron Lett. 2002, 43, 9089.

17. Distribution of Furamidine Analogues in Tumor Cells: Tartgeting of the Nucleus or Mitocondria Depending on Amidine Substitution. A. Lansiaux, F. Tanious, Z. Mishal, L. Dassonneville, A. Kumar, C. E. Stephens, Q. Hu, W. D. Wilson, D. W. Boykin, and C. Bailly, Cancer Res. 2002, 62, 7219.

18. Direct Conversion of Amidoximes to Amidines via Transfer Hydrogenation. M. Anbazhagan, D. W. Boykin, and C. E. Stephens, Synthesis 2003, 2467.

19. The Activity of Diguanidino and “Reversed” Diamidino 2,5-Diarylfurans versus Trypanosoma cruzi and Leishmania donovani. C. E. Stephens, R. Brun, M. M. Salem, K. A. Werbovetz, F. Tanious, W. D. Wilson, and D. W. Boykin, Bioorg. Med. Chem. Lett. 2003, 13, 2065.

20. Convenient and Improved Halogenation of 3,5-Diarylisoxazoles using N-Halosuccinimides. R. A. Day, J. A. Blake and C. E. Stephens, Synthesis 2003, 1586.

21. Inhibition of In Vitro Intracellular Growth of Trypanosoma cruzi by Dicationic Compounds. E. C. Heaton, D. M. Lai, E. C. Rowland, J. R. Seed, C. E. Stephens and D. W. Boykin, J. Parisitology 2003, 89, 1078.

22. Detection of Inhibition of Replication of Bovine Diarrhea Virus by Aromatic Dicationic Molecules. M. D. Givens, C. C. Dykstra, K. V. Brock, D. A. Stringfellow, A. Kumar, C. E. Stephens, H. Goker and D. W. Boykin, Antimicrob. Agents Chemother. 2003, 47, 2223.

23. Synthesis of Benzyloxybromobenzonitriles. M. A. Ismail, M. Anbazhagan, C. E. Stephens and D. W. Boykin, Synth. Comm. 2004, 34, 751.

24. Activities of Dicationic Compounds Against Trichomonas vaginalis. A. L. Crowell, C. E. Stephens, A. Kumar, D. W. Boykin and W. E. Secor, Antimicrob. Agents Chemother. 2004, 48, 3602.

25. Nuclear Fluorination of 3,5-Diarylisoxazoles with Selectfluor®. C. E. Stephens and J. A. Blake, J. Fluorine Chem. 2004, 125, 1939.

26. Inhibitory Effect of Dicationic Diphenylfurans on Production of Type I Collagen by Human Fibroblasts and Activated Hepatic Stellate Cells. B. Stefanovic, C. E. Stephens and D. W. Boykin, Life Sciences, 2005, 76, 2011.

27. Dications that Target the DNA Minor Groove: Compound Design and Preparation, DNA Interactions, Cellular Distribution and Biological Activity.Wilson, W. D.; Nguyen, B.; Tanious, F. A.; Mathis, A.; Hall, J. E.; Stephens, C. E.; Boykin, D.W. Current Med. Chem., Anti-Cancer Agents, 2005, 5, 389.

28. Aromatic Diamidines as Antiparasitic Agents. Soeiro, M. N. C.; De Souza, E. M.; Stephens, C. E.; Boykin, D.W. Expert Opin. Investig. Drugs 2005, 14, 957.

29. Unusual Dehydroxylation of Antimicrobial Amidoxime Prodrugs by Cytochrome b5 and NADH Cytochrome b5 Reductase. Saulter, J. Y.; Kurian, J. R.; Trepanier, L. A.; Tidwell, R. R.; Bridges, A. S.; Boykin, D. W.; Stephens, C. E.; Anbazhagan, M.; Hall, J. E. Drug Metab. Disp., 2005, 33, 1886.

30. Synthesis, DNA Affinity, and Antiprotozoal Activity of Fused Ring Dicationic Compounds. Arafa, R. K.; Brun, R.; Wenzler, T.; Tanious, F. A.; Wilson, W. D.; Stephens, C. E.; Boykin, D. W. J. Med. Chem., 2005, 48, 5480.

31. 3,5-Diarylisoxazoles: Individualized Three-Step Synthesis and Isomer Determination Using 13C- NMR and/or Mass Spectroscopy. C. E. Stephens and R. K. Arafa, J. Chem. Educ., 2006, 83, 1336.

32. Antiviral Properties of New Arylsulfone Derivatives with Activity Against Human Betaherpesviruses. Naesens, L.; Stephens, C. E.; Andrei, G.; Loregian, A.; De Bolle, L.; Zhang, Y.; Snoeck, R.; Sowell, J. W.; De Clercq, E. Antiviral Res., 2006, 72, 60.

33. CYP4F Enzymes are the Major Enzymes in Human Liver Microsomes that Catalyze the O- Demethylation of the Antiparasitic Prodrug DB289 [2,5-Bis(4-amidinophenyl)furan-bis-O- methylamidoxime]. Wang, M. Z.; Saulter, J. Y.; Usuki, E.; Cheung, Y.-L.; Hall, M.; Bridges, A. S.; Loewen, G.; Parkinson, O. T.; Stephens, C. E.; Allen, J. L.; Zeldin, D. C.; Boykin, D. W.; Tidwell, R. R.; Parkinson, A.; Paine, M. F.; Hall, J. E. Drug Metab. Disp., 2006, 34, 1985.

34. Oxidative Ring Opening of 2,5-Diarylfurans by Selectfluor. Blank, S. J.; Stephens, C. E. Tetrahedron Lett., 2006, 47, 6849.

35. Nuclear Fluorination of 2,4-Diarylthiazoles with Accufluor. Campbell, T. F.; Stephens, C. E. J. Fluorine Chem., 2006, 127, 1591.

36. An Efficient Synthesis of 5,5’-Diaryl-2,2’-bichalcophenes. Ismail, M. A.; Boykin, D. W.; Stephens, C. E. Tetrahedron Lett., 2006, 47, 795.

37. A New Synthesis of 2,5-Bis(4-cyanophenyl)furan. Suthiwangcharoen, N.; Stephens, C. E. Arkivoc, 2006 (xvi), 122.

38. Synthesis and Antiparasitic Evaluation of Bis-2,5-[4-guanidinophenyl]thiophenes. Gonzalez, J. L.; Stephens, C. E.; Wenzler, T.; Brun, R.; Tanious, F. A.; Wilson, W. D.; Barszcz, T.; Werbovetz, K. A.; Boykin, D. W. Eur. J. Med. Chem., 2007, 42, 552.

39. Activity of “Reversed” Diamidines Against Trypanosoma cruzi “in vitro”. Silva, C. F; Batista, M. M.; Mota, R. A.; de Souza, E. M.; Stephens, C. E.; Som, P.; Boykin, D. W.; Soeiro, M. N. C. Biochem. Pharm, 2007, 73, 1939.

40. In vitro Activity of Dicationic Compounds Against a North American Foxhound Isolate of Leishmania infantum. Rosypal, A. C.; Hall, J. E.; Bakunova, S.; Patrick, D. A.; Bakunov, S.; Stephens, C. E.; Kumar, A.; Boykin, D. W.; Tidwell, R. R. Vet. Parisitology, 2007, 145, 207.

41. Cellular Effects of Reversed Amidines on Trypanosoma cruzi. Silva, C. F.; Meuser, M. B.; De Souza, E. M.; Meirelles, M. N. L.; Stephens, C. E.; Som, P.; Boykin, D. W.; Soeiro, M. N. C. Antimicrob. Agents. Chemother. 2007, 51, 3803.

42. Host Cells Participate in the in vitro Effects of New-Generation Diamidine Analogues Against Tachyzoites of the Intracellular Apicomplexan Parasites Neospora caninum and Toxoplasma gondii. Leepin, A.; Studli, A.; Brun, R.; Stephens, C. E.; Boykin, D. W.; Hemphill, A. Antimicrob. Agents Chemother. 2008, 52, 1999.

43. A Modified Synthesis of Tellurophene using NaBH4 to generate Sodium Telluride. Sweat, D. P.; Stephens, C. E. J. Organometal. Chem. 2008, 693, 2463.

44. Inhibition by Dications of In Vitro Growth of Leishmania Major and Leishmania Tropica: Causitive Agents of Old World Cutaneous Leishmaniasis. Rosypal, A.; Werbovetz, K; Salem, M; Stephens, C. E.; Boykin, D. W.; Tidwell, R. R. J. Parasitol. 2008, 94, 743.

45. Heterocyclic Diamidine Interactions at AT Base Pairs in the DNA Minor Groove: Effects of Heterocyclic Differences, DNA AT Sequence and Length. Liu, Y.; Collar, C. J.; Kumar, A.; Stephens, C. E.; Boykin, D. W.; Wilson, W. D. J. Phys. Chem. B 2008, 112, 11809.

46. Trypanosoma cruzi: Activity of Heterocyclic Cationic Molecules in vitro. Pacheco, M. G de Oliveira; da Silva, C. F.; de Souza, E. M.; Batista, M. M.; da Silva, P. B.; Kumar, A.; Stephens, C. E.; Boykin, D. W.; Soeiro, M. N. C. Exp. Parasitology 2009, 123, 73.

47. Large, Sequence-Dependent Effects on DNA Conformation by Minor Groove Binding Compounds. Tevis, D. S.; Kumar, A.; Stephens, C. E.; Boykin, D. W.; Wilson. W. D. Nuc. Acids Res. 2009, 37, 5550.

48. Synthesis and Stille Cross-Coupling Reactions of 2-(Tributylstannyl)- and 2,5- Bis(trimethylstannyl)tellurophene. Sweat, D. P.; Stephens, C. E. Synthesis 2009, 3214.

49. In Vitro Activity and Preliminary Toxicity of Various Diamidine Compounds Against Trypanosoma evansi. Gillingwater, K.; Kumar, A.; Ismail, M. A.; Arafa, R. K.; Stephens, C. E.; Boykin, D. W.; Tidwell, R. R.; Brun, R. Veterinary Parasitology 2010, 169, 264.

50. Novel Arylimidamides for Treatment of Visceral Leishmaniasis. Wang, M. Z.; Zhu, X.; Srivastava, A.; Liu, Q.; Sweat, J. M.; Pandharkar, T.; Stephens, C. E.; Riccio, E.; Parman, T.; Munde, M.; Mandal, S.; Madhubala, R.; Tiwell, R. R.; Wilson, W. D.; Boykin, D. W.; Hall, J. E.; Kyle, D. E.; Werbovetz, K. A. Antimicrob. Agents Chemother. 2010, 54, 2507.

51. Arylimidamide DB766, a Potential Chemotherapeutic Candidate for Chagas’ Disease Treatment. Batista, D. J.; Batista, M. M.; Oliveira, G. M.; Amaral, P. B.; Lannes-Vieira, J.; Britto, C. C.; Junqueira, A.; Lima, M. M.; Romanha, A. J.; Junior, P. A. S.; Stephens, C. E.; Boykin, D. W.; Soeiro, M. N. C. Antimicrob. Agents Chemother. 2010, 54, 2940.

52. A Simple Mnemonic for Tautomerization Mechanisms in Organic Chemistry. Stephens, C. E. J. Chem. Ed. 2010, 87, 1186.

53. Aerobic Epoxidation and Hydroxylation of a Pyrrolo[2,1-b]quinazoline under Ambient Conditions. Hawkins, R. A.; Stephens, C. E. Tetrahedron Lett. 2010, 51, 6129.

54. DNA Minor Groove Induced Dimerization of Heterocyclic Cations: Compound Structure, Binding Affinity, and Specificity for a TTAA Site. Munde, M.; Kumar, A.; Nhili, R.; Depauw, S.; David-Cordonnier, M. H.; Ismail, M. A.; Stephens, C. E.; Farahat, A. A.; Batista-Parra, A.; Boykin, D. W.; Wilson, W. D. J. Mol. Biol. 2010, 402, 847.

55. Palladium-Catalyzed N-Arylation of 3-Functionalized 2-Amino-4,5-dimethylpyrroles. Griswold, C. P.; Suthiwangcharoen, N.; Pochini, S. M.; Stephens, C. E. Synth. Comm., in press.

56. An Intramolecular N-Arylation Approach to 3-Functionalized 4,9-Dihydropyrrolo[2,1- b]quinazolines. Suthiwangcharoen, N.; Pochini, S. M.; Sweat, D. P.; Stephens, C. E. J. Heterocyclic Chem., in press.

57. In vitro Effects of Arylimidamides Against Besnoitia besnoiti Infection in Vero Cells. Cortes, H. C. E.; Mueller, N.; Stephens, C. E.; Boykin, D. W.; Hemphill, A. Parasitology, in press.

58. In vitro Trypanocidal Activity of DB745B and Other Novel Arylimidamides Against Trypanosoma cruzi. da Silva, C. F.; Junqueira, A.; Lima, M. M.; Romanha, J.; Junior, P. A. S.; C. E. Stephens; P. Som; Boykin, D. W.; Soeiro, M. N. C. J. Antimicrob. Chemother., in press. (Back to Top)

Patents

1. Diguanidino and “Reversed” Diamidino Diaryl Furans and Thiophenes as Antimicrobial Agents. C. E. Stephens, F. Tanious, W. D. Wilson, W. A. Schell, J. R. Perfect, S. Franzblau, D. W. Boykin, patent application filed 11/6/00 (Patent#60/246,244).

2. Reversed Amidines and Methods of Using them for Treating, Preventing, or Inhibiting Leishmaniasis. K. Werbovetz, J. Brendle, C. E. Stephens, D. W. Boykin, US Patent 6,706,754 (Filed 11/05/01).

3. Fused Ring Dicationic Anti-Protozoan Agents and their Prodrugs. David W. Boykin, W. David Wilson, Reem K. Arafa, and Chad E. Stephens, patent application filed 11/24/03 (Patent#60/525,018).

4. Synthesis and Anitimicrobial Activity of Novel Dicationic “Reversed Amidines”. Boykin, D. W.; Tidwell, R. R.; Wilson, W. D.; Perfect, J. R.; Stephens, C. E. US Patent No. 6,737,440 B2, 2004.

5. 5,5’-Bis(4-amidinophenyl)-2,2’-bifuran Derivatives and Related Compounds as Antiprotozoal Agents and Prodrugs Thereof. K. Werbovetz, R. Brun, R. R. Tidwell, D. W. Boykin, C. E. Stephens, M. A. Ismail, W. D. Wilson, patent application 5/19/06 (Eur Patent Application, Patent #: 06114189.1-2101).

6. 2,5-Diarylselenophene Compounds, Aza 2,5-Diarylthiophene Compounds, and Their Prodrugs as Antiprotozoal Agents. R. R. Tidwell, D. W. Boykin, C. E. Stephens, M. A. Ismail, A. Kumar, W. D. Wilson, R. Brun, and K. Werbovetz. US Provisional Patent #421-60-34, 2006.

7. Dicationic Compounds for Activity Against Trichomonas Vaginalis. D. W. Boykin, C. E. Stephens, W. E. Secor, A. L. Crowell, and A. Kumar. US Patent# US 2007/0276020 A1, 2007.

8. Compounds, Methods and Compositions for the Treatment of Bovine Diarrhea Virus (BVDV) and Hepatitis C Virus (HCV) Infection. C. C. Dykstra, M. D. Givens, D. A. Stringfellow, K. Brock, D. W. Boykin, A. Kumar, W. D. Wilson, R. R. Tidwell, and C. E. Stephens. U. S. Patent No. 7,410,989, 2008.

9. Bichalcophenes and their Prodrugs as Antiprotozoal Agents. R. R. Tidwell, D. W. Boykin, C. E. Stephens, M. A. Ismail, W. D. Wilson, R. Brun, and K. Werbovetz. US Patent No. 7,517,893, 2009.  (Back to Top)

Conference Abstracts

1. Chain-Length Variation in N-Alkyl-2-Piperidones: The Effect on Enhancement Activity In Vitro. K. D. Lebby, N. Kim, C. E. Stephens, J. W. Sowell, Sr., and B. B. Michniak, Pharmaceutical Research, 14 (11), S-307 (1997). Presented at the 17th Annual Graduate Research Association of Students in Pharmaceutics National Meeting, Gainesville, FL, June 6-8, 1997.

2. Quantification of the Prodrug DB289 and an Active Metabolite, DB75, in Rat and Monkey Plasma Using SPE, Liquid Chromatrography and Electrospray Ionization Tandem MassSpectrometry. K. L. Trendler, J. A. Allen, J. E. Hall, C. E. Stephens, S. A. Reuschel, G. M. Eagle, and P. K. Bennett.

3. Antiviral Activity of 2H-3-(4-Chlorophenyl)-3,4-dihydrobenzo[1,4]thiazine-2-carbonitrile 1,1-Dioxide Against Human Betaherpesviruses. L. Naesens, G. Andrei, Y. Zhang, C. E.Stephens, J. Walter Sowell, Sr., L. De Bolle, R. Snoeck, and E. De Clercq, International Conference on Antiviral Research, Seattle, WA, April, 2001.

4. Anti-Betaherpesvirus Activity of the Non-Nucleoside Analogue 2H-3-(4-Chlorophenyl)-3,4-dihydrobenzo[1,4]thiazine-2-carbonitrile 1,1-Dioxide, L. Naesens, G. Andrei, Y. Zhang, C. E. Stephens, J. Walter Sowell, Sr., L. De Bolle, R. Snoeck, and E. De Clercq, 4th International Conference on Human Herpesviruses 6, 7, and 8, Paris, France, May, 2001.

5. Absorption, Distribution and Metabolism of DB289, an Orally Active Prodrug for Treatment of African Trypanosomiasis. L. Zhou, J. E. Hall, J. Zong, G. M. Pollack, J. R. Seed, J. L. Allen, P. Yeramian, L. McChesney-Harris, J. M. Ndung’u, R. Mdachi, J. Ngotho, R. Brun, C. E. Stephens, M. Anbazhagan, D. W. Boykin, and R. R. Tidwell, 4th COST-B9 Congress on Antiprotozoal Chemotherapy, Lisbon, Portugal, May 6-9, 2001.

6. Synthesis and Evaluation of the Antitrypanosomal Activity of Novel Dicationic Diamidino,Diguanidino and “Reversed Amidines” in the 2,5-Diarylfuran Series. C. E. Stephens, W. D. Wilson, R. Brun, J. E. Hall, J. R. Seed, R. R. Tidwell, J. M. Ndung’u, R. Mdachi, and D. W. Boykin, 4th COST-B9 Congress on Antiprotozoal Chemotherapy, Lisbon, Portugal, May 6-9, 2001.

7. Antileishmanial Activity of Aromatic Dications. K. Werbovetz, J. Brendle, C. Stephens, C. Heiney, K. de Luca-Fradley, S. Croft, R. Tidwell, and D. W. Boykin, 4th COST-B9 Congress on Antiprotozoal Chemotherapy, Lisbon, Portugal, May 6-9, 2001.

8. Inhibition of In Vitro Intracellular Growth of Trypanosoma Cruzi by Dicationic Compounds. Heaton, E. C., Lai, D. M., Rowland, E. C., Seed, J. R., Stephens, C. E., Boykin, D. W., American Society of Trop. Med. and Hygiene, 50th Annual Meeting, Atlanta, GA, Nov. 2001.

9. Synthesis and Antileishmanial Activity of Novel Dicationic “Reversed Amidines” and Guanidines in the 2,5-Diarylfuran Series. C. E. Stephens, K. Werbovetz, A. Outlaw, J. Brendle, K. de Luca-Fradley, S. Croft, D. W. Boykin, American Society of Trop. Med. and Hygiene, 50th Annual Meeting, Atlanta, GA, Nov. 14, 2001.

10. A Novel Fragmentation Pathway Involving Formation of Radical Product Ions from an Antimicrobial Prodrug DB289 and Selected Metabolites Using Ion Trap Mass Spectrometry. Lian Zhou, Robert D. Voyksner, Dhiren R. Thakker, Chad E. Stephens, Mariappan Anbazhagan, David W. Boykin, James E. Hall, Richard R. Tidwell. The 50th ASMS Conference, Orlando, June 6, 2002.

11. Metabolism of a novel antimicrobial prodrug, 2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime. L. Zhou, R. D. Voyksner, D. R. Thakker, P. Annaert, C. E. Stephens, D. W. Boykin, J. E. Hall, and R. R. Tidwell. The 2002 Experimental Biology, New Orleans, A561, April 20, 2002. FASEB Journal, 16 (4): A561 Part 1.

12. Thermodynamic and Structural Studies on a Novel Class of Benzimidazole Derivatives that Bind to the Minor Groove of DNA. S. Mallena, A. Kumar, A. Batista-Parra, C. E. Stephens, D. W. Boykin, W. D. Wilson. ACS Abstract 276-MEDI, ACS National Meeting, New York, NY, September, 2003.

13. Synthesis of Novel Furan-Substituted Amidines, Reversed Amidines, and Guanidines in the 2,5-Diarylfuran Series as Potential Antimicrobial Agents. Phanneth Som, Karl Werbovetz, Chad Stephens, David Boykin. SERMACS, Atlanta, GA, November, 2003.

14. Studies on the Structure and Thermodynamics on a Series of Benzimidazole Derivatives that Bind in the Minor Groove of DNA. Sirish Mallena, Arvind Kumar, Chad Stephens, Adalgisa Batista-Parra, David Wilson, David Boykin. SERMACS, Atlanta, GA, November, 2003.

15. Fluorination of 2,4-Diphenylthiazoles with the N-F Reagent Accufluor. Timmeda Campbell, Chad E. Stephens. ACS National Meeting, Atlanta, GA, March, 2006, ORGN 509.

16. Analysis of Reverse Amidine-DNA Minor Groove Complexes. M. Munde, R. K. Arafa, C. E. Stephens, A. Kumar, D. W. Boykin, W. D. Wilson. ACS National Meeting, Atlanta, GA, March, 2006, PHYS 386.

17. Different DNA Conformational Changes Caused by DNA Minor Groove Binding Cations with Different Groove Shape. Y. Liu, A. Kumar, C. E. Stephens, D. W. Boykin, W. D. Wilson. ACS National Meeting, Atlanta, GA, March, 2006, PHYS 377.

18. A New Synthesis of 2,5-Bis(4-cyanophenyl)furan. Nisaraporn Suthiwangcharoen, Chad E. Stephens. ASU PKP Student Research Day Conference, March, 2006.

19. Electrophilic Fluorination of 2,5-Diphenylthiazoles with Various N-F Reagents. Julie M. Hatfield, Chad E. Stephens. SERMACS, Abstract 684, Augusta, GA November, 2006.

20. Synthesis of Bicyclic Sulfone Derivatives as Potential Non-Nucleoside Inhibitors of Human Betaherpesviruses. Daniel R. Gerry, Chad E. Stephens. SERMACS, Abstract 685, Augusta, GA November, 2006.

21. A New Synthesis of the Pyrrolo[2,1-b]quinazoline System by Intramolecular N-Arylation. Nisaraporn Suthiwangcharoen, Chad E. Stephens. SERMACS, Abstract 686, Augusta, GA November, 2006.

22. Electrophilic Fluorination of 2,5-Diphenylthiazoles with Various N-F Reagents. Julie M. Hatfield, Chad E. Stephens. ASU PKP Student Research DayConference, March, 2007.

23. Synthesis of Bicyclic Sulfone Derivatives as Potential Non-Nucleoside Inhibitorsof Human Betaherpesviruses. Daniel R. Gerry, Chad E. Stephens. ASU PKP Student Research Day Conference, March, 2007.

24. A New Synthesis of the Pyrrolo[2,1-b]quinazoline System by Intramolecular N- Arylation. Nisaraporn Suthiwangcharoen, Chad E. Stephens. ASU PKP Student Research Day Conference, March, 2007.

25. Optimization of the Heterocyclic Synthesis of 2-Amino-4,5-Diphenylfuran-3-Carbonitrile for the Organic Teaching Laboratory. Paul S. Howell, Chad E. Stephens. ASU PKP Student Research Day Conference, March, 2007.

26. Tuning the Binding Affinity and Sequence Selectivity for Alternating and Nonalternating at DNA of Heterocyclic Diamidines. Yang Liu, Arving Kumar, Chad E. Stephens, David W. Boykin, W. David Wilson, SERMACS, Abstract 606, Greenville, SC, Oct. 2007.

27. Palladium Catalyzed N-Arylation of 2-Amino-1-Benzyl-4,5-Dimethyl-3R-Pyrroles. Carlos P. Griswold, Nisaraporn Suthiwangcharoen, Steven M. Pochini, Chad E. Stephens. SERMACS, Abstract 663, Greenville, SC, Oct. 2007.

28. Heterocyclic Chemistry in the Teaching Laboratory: Synthesis of 2-Amino-3-cyano-4,5-dimethylfuran and –pyrrole Using Either Sonication or Microwave Irradiation. Aditya Parikh, Paul S. Howell, Chad E. Stephens. SERMACS, Abstract 774, Greenville, SC, Oct. 2007.

29. A Modified Synthesis of Tellurophene and Various Stille Couplings of the Mono- and Distannane Derivatives. Daniel P. Sweat, Chad E. Stephens. SERMACS, Abstract 775, Greenville, SC, Oct. 2007.

30. Aromatization of Various 1,3,5-Triarylpyrazolines to Pyrazoles Using DMSO as Oxidant. George M. Hinnant, Jason W. Eades, Chad E. Stephens. SERMACS, Abstract 776, Greenville, SC, Oct. 2007.

31. Electrophilic Fluorination of 5-Member Ring Heterocycles with N-F Reagents. Chad E. Stephens. Presented at the “Fluorine Containing Molecules and Polymers” symposium, SERMACS, Abstract 272, Greenville, SC, Oct. 2007.

32. Heterocyclic Chemistry in the Teaching Laboratory: Synthesis of 2-Amino-3-cyano-4,5-dimethylfuran and –pyrrole Using Either Sonication or Microwave Irradiation. Aditya Parikh, Paul S. Howell, Chad E. Stephens. ASU PKP Research Day Conference, March, 2008.

33. Synthesis of Tellurophene and Stille Couplings of the Tin Derivatives. Daniel P. Sweat, Chad E. Stephens. ASU PKP Research Day Conference, March, 2008.

34. Variable Chemoselectivity in the Nitro Reduction of 1-Cyanomethylsulfonyl-2-Nitrobenzene. Joseph E. Banning, Chad E. Stephens. ASU PKP Research Day Conference, March, 2008.

35. Nuclear Fluorination of Various 1,3,5-Triphenylpyrazoles with NFS. Jason W. Eades, George M. Hinnnant, LeAnn Walton, Chad E. Stephens. ASU PKP Research Day Conference, March, 2008

36. Synthesis of a Dehydrogenated Analogue of a Potent HHV-6 Inhibitor. Phillip D. Wilkerson, Chad E. Stephens. ASU PKP Research Day Conference, March, 2009

37. Novel Tricyclic Heterocycles via Intramolecular N-Arylation of 2-Aminopyrroles and thiophenes. Brandon L. Hammond, Chad E. Stephens. ASU PKP Research Day Conference, March, 2009

38. Synthesis and Fluorination of Various 1,3,5-Triarylpyrazoles. Ronnie Neil Jenkins, Jr., Chad E. Stephens. ASU PKP Research Day Conference, March, 2009

39. Synthesis of N-Substituted Analogues of a Potent HHV-6 Inhibitor. Gary M. Schwarz, Chad E.Stephens. ASU PKP Research Day Conference, March, 2009

40. Synthesis of the Thiophene Analogue of a Potent Antiprotozoal Agent. Mary Kate Fisher, Chad E.Stephens. ASU PKP Research Day Conference, March, 2009

41. Electrophilic Halogenation of Sulfanilamide in the Organic Teaching Laboratory. Akshita Parikh, Van Beaty, Leila Borders, Aiko Bradford, Scarlett Timmons, Chad E.Stephens. ASU PKP Research Day Conference, March, 2009

42. Mono- and Trifluorination of the Heterocyclic Ring of 2,5-Diarylthiazoles Using an N-F Reagent. Julie M. Hatfield, Chad E. Stephens. 19th International Symposium on Fluorine Chemistry, Abstract 244, Jackson, WY, Aug., 2009.

43. Chemoselective Reduction of 1-Cyanomethylsulfonyl-2-nitrobenzene, an Intermediate in the Synthesis of New HHV-6 Inhibitors. Phillip D. Wilkerson, Chad E. Stephens. Abstract #233. 61st Southeast Regional Meeting of the American Chemical Society, Puerto Rico, Oct., 2009.

44. Electrophilic Dihalogenation of Sulfanilamide in the Organic Teaching Laboratory. Van Beaty, Chad E. Stephens. Abstract #230. 61st Southeast Regional Meeting of the American Chemical Society, Puerto Rico, Oct., 2009.

45. Synthesis of a Dehydrogenated Analogue of a Potent HHV-6 Inhibitor. Phillip D. Wilkerson, Chad E. Stephens. Abstract #397. 61st Southeast Regional Meeting of the American Chemical Society, Puerto Rico, Oct., 2009.

46. Synthesis and Fluorination of Various 1,3,5-Triarylpyrazoles. Ronnie Neil Jenkins, Jr., Chad E. Stephens. Abstract #425. 61st Southeast Regional Meeting of the American Chemical Society, Puerto Rico, Oct., 2009.

47. Synthesis and Fluorination of Various 1,3,5-Triarylpyrazoles. Ronnie Neil Jenkins, Jr., Chad E. Stephens. Abstract #P9. ASU PKP Research Day Conference, March, 2010.

48. Attempted Oxidation of Pyrrolo[2,1-b]quinazolines with Formation of a Stable Epoxide. Ryan Hawkins, Chad E. Stephens. Abstract #H1. ASU PKP Research Day Conference, March, 2010.

49. Synthesis of 2-Aminofluorene Derivatives as an Organic Chemistry Laboratory Project. Joy Harris, Chad E. Stephens. Abstract #H2. ASU PKP Research Day Conference, March, 2010.

50. Synthesis of Analogues of Dapsone as Potential DNA Binding Compounds. Craig Atkins, Chad E. Stephens. Abstract #H5. ASU PKP Research Day Conference, March, 2010.

51. 3-Arylfuran “Reversed” Diamidines as Potential Inhibitors of Leishmania and Trypanosoma cruzi. Holley Burke, Chad E. Stephens. Abstract #H6. ASU PKP Research Day Conference, March, 2010.

52. Synthesis of a Cyclopentyl Derivative of an Antiprotozoal Reverse Diamidine. Lindsay Hilkert, Chad E. Stephens. Abstract #BR9. ASU PKP Research Day Conference, March, 2010.

53. Synthesis of C-Substituted Bicyclic Sulfones as Potential HHV-6 Inhibitors. Zoe Renew, Chad E. Stephens. Abstract #BR10. ASU PKP Research Day Conference, March, 2010.

54. Chemoselective Reduction of 1-Cyanomethylsulfonyl-2-nitrobenzene, an Intermediate to Potential HHV-6 Inhibitors. Phillip D. Wilkerson, Chad E. Stephens. Abstract #BR11. ASU PKP Research Day Conference, March, 2010.

55. Synthesis of 2-Aminofluorene Derivatives as an Organic Chemistry Laboratory Project. Joy T. Jenkins, Michele Siewe, Chad E. Stephens. Abstract #P11. ASU PKP Research Day Conference, March, 2011.

56. The DNA Binding Preferences of Four Different Dapsone Derivatives. J. Rafferty, A. Gorensek, K. C. Atkins II, C. Stephens, K. L. Buchmueller. Abstract #1070. 66th Southwest and 62nd Southeastern Regional Meeting of the American Chemical Society, New Orleans, Dec. 2010.

57. Hydration of Diphenylacetylene Without a Mercury Catalyst: An Expanded Teaching Lab. Miranda L. Emery, Chad E. Stephens. Abstract #P10. ASU PKP Research Day Conference, March, 2011.

58. Synthesis of New Mono Reverse Amidines as Potential Inhibitors of Leishmaniasis or Chagas’ Disease. Wesley A. Black, Chad E. Stephens. Abstract #H4. ASU PKP Research Day Conference, March, 2011.

59. Synthesis and Cyclization of Various 2-Aminopyrroles to Tricyclic Compounds. Joseph W. Price, Chad E. Stephens. Abstract #Bu1. ASU PKP Research Day Conference, March, 2011.

60. Synthesis of 4,4-Difluoro-3,5-Diphenylpyrazole as a Potential Precursor to gem-Difluorinated Cyclopropanes. Thomas B. Tinkle, Chad E. Stephens. Abstract #Bu2. ASU PKP Research Day Conference, March, 2011. (Back to Top)